Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019 / Bordoni, V.; Sacchi, A.; Cimini, E.; Notari, S.; Grassi, G.; Tartaglia, E.; Casetti, R.; Giancola, M. L.; Bevilacqua, N.; Maeurer, M.; Zumla, A.; Locatelli, F.; De Benedetti, F.; Palmieri, F.; Marchioni, L.; Capobianchi, M. R.; D'Offizi, G.; Petrosillo, N.; Antinori, A.; Nicastri, E.; Ippolito, G.; Agrati, C.. - In: CLINICAL INFECTIOUS DISEASES. - ISSN 1058-4838. - 71:16(2020), pp. 2272-2275. [10.1093/cid/ciaa577]
An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019
Locatelli F.;
2020
Abstract
Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.| File | Dimensione | Formato | |
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